Abstract: The stability of antioxidant and hypoglycemic activity from Myrica rubra peptide were determined with the effects of temperature,p H,saccharides,antiseptics and metal ions on the DPPH radicals scavenging activity and α-glucosidase inhibition activity assessed,but also investigated its relative molecular mass distribution. The result showed that the relative molecular mass distribution of Myrica rubra peptide range from118.9 ~4552.2u with an excellent heat-resistant and heat-resistant ability. But antioxidant activity lost and hypoglycemic activity rose slightly in the alkali environment. Saccharides could increase the antioxidant activity significantly in the order of glucose >lactose >sucrose. Both benzoic acid and Na Cl had no effects on antioxidant activity. Benzoic acid had no significant effects on hypoglycemic activity( p > 0. 05), but Na Cl improved the hypoglycemic activity from 1.5% to 2%. Both Cu2 +and Zn2 +reduced the antioxidant and hypoglycemic activity. Mg2+and K+had no significant effects on antioxidant activity(p>0.05),but hypoglycemic activity was slightly enhanced by Mg2+and K+had no significant effects on hypoglycemic activity(p>0.05).