青刺尖茶对高血脂症小鼠降脂的效果

杨妍; 刘刚; 张晓喻; 胡婷婷; 王战国; 黎霞; 李慧敏

doi:10.13386/j.issn1002-0306.2015.13.067

青刺尖茶对高血脂症小鼠降脂的效果

Effect of Prinsepia utilis tea on blood lipids in hyperlipidemic mice

摘要

摘要: 目的:探讨青刺尖茶汤对高血脂症模型小鼠的降血脂作用。方法:高脂饲料喂养小鼠28d,建立高血脂症模型小鼠后随机分成5组,即模型组、青刺尖茶汤低、中和高3个剂量处理组（2、6和9g/kg·bw）及血脂康阳性组（3g/kg·bw）,以普通饲料喂养的同批小鼠作空白组。实验期间各组小鼠取食正常,毛洁白具光泽,且无排稀便现象。进行连续灌胃给药28d,心脏取血分离血清,检测总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）的含量,同时,计算肝脏指数及小鼠体重的增长量。结果:与模型组比较,各处理组的血清TG、LDL-C均显著降低（p<0.05）,血清TC、HDL-C和肝脏指数均极显著降低（p<0.01）;高剂量组的血清LDL-C与模型组的差异也达到极显著（p<0.01）。与空白组比较,各处理组体重的增长量均降低,低、中剂量组达极显著（p<0.01）,高剂量组为显著（p<0.05）,同时,模型组的肝脏指数显著升高（p<0.05）,但各处理组的肝脏指数无显著差异。与模型组比较,各处理组体重的增长量、肝脏指数的降低,均呈现极显著（p<0.01）。与阳性组比较,各处理组体重的增长量、肝脏指数,均无差异性。结论:青刺尖茶汤具有控制高血脂症小鼠体重的增加、降低肝脏指数的作用,并显示良好的降低血清4项血脂指标的功效,因此,青刺尖茶具有降低高血脂症小鼠血脂的效果,显示其降血脂功能。

Abstract: Objective: To study the effect of Prinsepia utilis tea on blood lipid in mouse model of hyperlipidemia.Method: The hyperlipidemia mouse model was induced by high fat diet successfully and the mice were randomly divided into blank group, model group, low ( 2g / kg·bw) , middle ( 6g / kg·bw) , high ( 9g / kg·bw) dose group of Prinsepia utilis tea and positive in group. After treatment of 28 d by gastric gavage, serum total cholesefol ( TC) , riglyceride ( TG) , high density lipoprotein cholesterol ( HDL- C) and low density lipoprotein cholesterol ( LDL- C) levels were measured by automatic biochemical analyzer, liver index was calculated.Result: Serum TG and LDL- C in Prinsepia utilis tea groups were notably lower than model group ( p < 0.05) ; serum TC, HDL- C, weight increase and liver index were significantly lower than model group ( p < 0.01) , LDL- C in high dose group was significantly lower than model group ( p < 0.01) .Weight increase in Prinsepia utilis tea groups were lower than blank group, low and middle dose group was significantly lower than blank group ( p < 0.01) , high dose group were notably lower than blank group ( p < 0.05) , liver index in model group was notably higher than blank group ( p < 0.05) .Compared each Prinsepia utilis tea group with model group, TC, TG, LDL- C, HDL- C, weight increase and liver index were not significantly different.Conclusion: Prinsepia utilis tea has weight relief and evident hypolipemia effect.