Abstract: Ilex and Litchi as two raw materials, with the total flavonoids extraction rate from Ilex as an indicator, using Box- Behnken response surface methodology based on single factor investigations, and the optimum conditions were defined as follows: the ratio of solid to liquid ( w / v) 1∶33, extracting temperature 62℃, extracting time 129 min.Under this condition, the total flavonoids extraction rate was 34.656 mg / g.Finally, the optimum production conditions was obtained by the orthogonal experiment, and the results showed that: tea liquor 1.0%, litchi juice 15%, sugar7%, citric acid 0.15%, and the score was 95.