Abstract: Molecular imprinted solid phase extraction (MISPE) shows great advantage in meat safety detection technology for its good selectivity, recognition, and the accuracy of analysis etc. In this article, the application of molecularly imprinted solid-phase extraction technology in pesticide residue, veterinary drug residue, heavy metal residue in meat security detection had been systematically reviewed by comparing with commonly used methods. Furthermore, the problem that had brought from the technology were analyzed and prospected to provide a reference for the development of meat food safety testing technology.