Abstract: Microalgae had lots of species, and they were widely distributed. The comprehensive processing and related products development of microalgae had caught great attention. Nowadays, microalgae were mainly used for the preparation of renewable energy sources, biological active substances and functional feed. It was widely used in many fields such as chemical, farming, health care, food and cosmetics, helps solving series problems of energy, environment and health issues for mankind, which has an important economic value and development potential. This paper reviewd the recent progress of comprehensive processing and utilization of microalgae, and aimed to provide a reference for deep processing and product development of microalgae.