Abstract: The citrus bioactive compounds has been wildly concerned because of it 's function of medical and health care,such as antioxidant,anticancer,anti- cardiovascular disease,anti- inflammatory,anti- allergic and anti- microbial.The evolution of citrus bioactivity became a hot topic of the world.In this paper,the recent literature on the bioactivator and its role in chronic disease prevention and treatment were reviewed.The new advances made in the cure mechanism and related areas were summarized in an attempt to provide new information for future exploitation and utilization of rich citrus genetic resources in China.