莲心超微粉碎提高有效成分的溶出速率

Effect of superfine grinding of Lotus nut on the release rates of active ingredients

摘要: 为提高莲心中功能成分的溶出速率,本实验研究了莲心水分含量、预粉碎、Si O2添加量、以及气流粉碎设备的操作参数(粉碎压力、进料压力)对莲心超微粉碎的影响,并且探讨了不同粒度的莲心粉在不同溶剂中的有效成分溶出速率。结果表明:减少水分含量,预粉碎处理,添加30%抗结剂Si O2,以及合适的超微粉碎压力(70Psi)和进料压力(100Psi)有利于超微粉碎,得到粒径为4~18μm的莲心粉。超微化处理可以明显提高莲心有效成分在水和无水乙醇中的溶出速率但不利于其在人工胃液中溶出。

Abstract: In order to improve the release rate of functional components in Lotus nut, the effects of moisture content, pre- grinding, amount of Si O2 added, and operation parameter of air flow pulverizer on superfine grinding of Lotus nut was researched.Furthermore, the release rates of active ingredients of Lotus nut with different particle sizes in various solvents were analyzed. The results showed that reduction of moisture content, pre- grinding, addition of Si O2, as well as a suitable crush pressure ( 70Psi) and feed- in pressure ( 100Psi) was beneficial to superfine grinding, the particle size of final Lotus nut power was 4 ~ 18μm. The super- fine treatment could speed up the release rates significantly when water and alcohol were used as solvent but not for the case that simulated gastric fluid was used.