Abstract: Osteoporosis is a global problem.Although the drugs have curative effect, they still have the security risk and high prices problem. In recent years, scholars always focused on natural active ingredients extracted from plant.In this review, four kinds of important plant polyphenols, the present situation of their anti-osteoporosis activity and interaction mechanisms were summarized, in order to find some new anti-osteoporosis drugs, which were also safe and effective.