Abstract: This paper dealed with the optimization of the process conditions for the extraction technique of proanthocyanidin from eggplant peel using response surface methodology (RSM) . Experimental factors and their levels were determined by one-factor tests. Subsequently, the Box-Benhnken experimental design with 4factors and 3 levels was performed, and the factors influencing the extracted technology were estimated by means of regression analysis. Response surface and contour were finally graphed with the extraction yield of proanthocyanidin from eggplant peel as the response value. The results showed that the optimal conditions of extraction were obtained as follows:solid to solvent ratio at 1∶50 (g/mL) , concentration of alcohol 71%, temperature71℃, time 88 s. Under these conditions, the experimental yield of proanthocyanidin was 3.860%, which was in substantial agreement with the theoretically predicted values.