天然酪氨酸酶抑制剂研究进展:种类及其构效关系

Research progress in natural tyrosinase inhibitors:types and structure-activity relationships

摘要: 酪氨酸酶广泛存在于生物体中,是调节生物体内黑色素合成的一个关键酶。然而,不正常的黑色素生成,会带来许多不利的影响。利用酪氨酸酶抑制剂对酪氨酸酶的活性进行抑制,进而抑制黑色素的产生,在医药、食品和化妆品等领域,是一种行之有效的方法。本综述对国内外报道的天然酪氨酸酶抑制剂进行系统的总结,并对它们的构效关系进行讨论,为开发酪氨酸酶抑制剂提供科学的参考。

Abstract: Tyrosinase widely presents and that is a key enzyme in the organism, which plays important role in synthesis of melanin. However, excessive abnormal melanin will bring many adverse effects. Application of tyrosinase inhibitors has been one of the most popular and desirable strategies to control the excessive abnormal melanin in pharmaceutical, food and cosmetics. In this review, natural tyrosinase inhibitors were systematically summarized and their structure- activity relationships were also discussed, which would contribute to the future development of tyrosinase inhibitors.