1,8-桉叶油素对小鼠的经口急性毒性和蓄积毒性的研究

The oral acute and accumulative toxicity of 1, 8-cineole on mice

摘要: 采用改良寇氏法测试了1,8-桉叶油素对小鼠的急性毒性,并采用固定剂量蓄积毒性系数法测试了其蓄积毒性。结果表明,1,8-桉叶油素对小鼠经口半数致死剂量（LD50）为3847.34mg/kg.bw,95%置信限为3352.80⁴414.82mg/kg.bw,急性中毒主要靶器官为肝脏和肾脏;小鼠蓄积性毒性实验所得蓄积系数K>5,与对照组相比,1,8-桉叶油素对小鼠饲料利用率与脏器系数无明显影响（p>0.05）,对脏器无明显不良影响。可见1,8-桉叶油素对小鼠属于低毒化学物质,无明显蓄积毒性。

Abstract: The oral acute toxicity of 1, 8- cineole on mice was tested by the modified Karber method, and the oral accumulative toxicity was carried out by a fixed dose method.The results showed that the half-lethal dose ( LD50) of1, 8-cineole was 3847.34 mg /kg.bw with the 95% confidence interval of 3352.80 ~ 4414.82mg /kg.bw. The liver and kidney were the key targets organ of acute poisoning of 1, 8- cineole on mice. The accumulative toxicity test revealed that the accumulative coefficient K was larger than 5.No obviously influence of 1, 8- cineole on the feed conversion rate and organ coefficient of mice was observed compared to the control group ( p > 0.05) .1, 8-cineole exhibited no obviously harmful effects on organ of mice.1, 8-cineole displayed low acute toxicity and no obviously accumulative toxicity.