Abstract: Microwave-assisted extraction (MAE) of flavonoids from Corylus heterophylla leaves was investigated.Effects of several experimental parameters, such as solvent concentration, temperature, microwave power, and microwave irradiation time, on the extraction yield of flavonoids from Corylus heterophylla leaves were evaluated.The optimal conditions of MAE used were extraction with 55% ethanol as solvent, solid-liquid ratio 1∶35 (g∶ mL) , a microwave power of 300W, 80℃, and microwave irradiation time 5min.Thereafter, the macroporous adsorbent resin was used to enrich the flavonoids in the crude extract.The adsorption and desorption of eight macroporous adsorbent resins for flavonoids were compared.The optimal adsorbent was D101.The optimal adsorption /desorption conditions were determined as follows: pH4 for sample solution, the extract solution passed through the column at a flow rate of 2BV/h, the column was washed with 3BV, pH4, 70% alcohol at a flow rate of 2BV/h.The purity of flavonoids was increased to 54.7%.