Abstract: This article with curcumin, ferulic acid, vanillin as the research object, to research the influence of single-frequency ultrasound , double-frequency compound ultrasonic and double-frequency alternating ultrasound to curcumin degradation and the other two materials generation. By using homogenous design experiments, ferulic acid as the goal to optimize the design of the product, under the ultrasonic frequency 50kHz, ultrasonic power 100W, 65℃ , 30% ethanol, pH11, ferulic acid concentration was 0.81mg/L, the most productive was got. 50/135kHz -frequency ultrasonic frequency alternating conditions, ultrasonic power 20W, temperature 80℃ , ethanol concentration 70% , pH11, vanillin concentration was 2.93mg/L, the most productive was got. Results indicated that, ultrasonic in high temperature alkaline environment, curcumin would degraded into ferulic acid and vanillin. By changing these conditions to promote the degradation of curcumin, thus provided another way to preparation of ferulic acid and vanillin.