Abstract: Objective:To observe the effect of apple pomace polyphone on weight and lipid metabolism in high- lipid rats.Methods:Totally 60 rats were randomly divided into 6 groups.Five groups were fed with high fat diet except for the normal control group.High-lipid rats were administered by gavage with apple pomace polyphonel according to low, middle and high dose, and positive control group (Fenofibrate) was established. High-lipid rats were administered by gavage continually with apple pomace polyphone and fenofibrate for 28d, and then the body weight, TC, TG, HDL-C, LDL-C and AI levels of rats were measured.Results:Apple pomace polyphone could obviously reduce (p<0.05) the contents of TG, TC, LDL-C and AI.In contrast, it could also improve HDL-C in serum (p<0.05) .TC, HDL-C and LDL-C three index, effects of apple pomace polyphone were better than those of fenofibrate.The TC index, fenofibric was slightly better than that of apple pomace polyphone.Losing weight of high-lipid rats index, the effect of apple pomace polyphone was much better than that of fenofibrate.Conclusion:Apple pomace polyphone had effective function of lowing serum lipid, losing weight and mitigation of atherosclerosis of high-lipid rats.