Abstract: Sulfonamides drugs is one kind of broad spectrum antibacteria agent, because its low price and stable performance, it is widely used in the treatment of infectious diseases of livestock and poultry, and veterinary.Improper use of this medicine causes its enrichment in animal or ganism and result in side effects to environment and human body directly or in directly, and it further causes the raise of bacteria resistance of human body, in the meanwhile, it has became a security risk to the animal derived food.In order to fully learn the detection status of sulfonamides drugs residues in the animal derived food, the paper summerised the sample pre-processing and detection methods to the sulfonamides drugs residues in the animal derived food.