Abstract: Mice were fed with fat-rich forage plus ethanol infusion for 30d in order to make model success. The injured mice were randomly and averagely divided into four groups:high, medium and low dose of Euphausia Superba oil groups and natural recovery group. At the same time, a normal group was set as control group.The mice in each group were treated with different reagents for 10d and detected related biochemical and pathological index, respectively. As a result, compared with natural recovery group, the levels of serum lipids including the triglyceride ( TG ) , total cholesterol ( TC ) decreased and the levels of glutamic-oxalacetic transaminease (AST) , glutamic-pyruvic transaminase (ALT) also decreased in Euphausia Superba oil groups (p<0.01 or p<0.05) . After treatment of Euphausia Superba oil, the levels of TG and TC in hepatic tissue were lower than those in natural recovery group (p<0.01 or p<0.05) . The frozen sections of fat dyeing results showed that the accumulation of lipid in liver cell droped significantly in Euphausia Superba oil groups.