太子参多糖对糖尿病小鼠抗氧化能力与胰腺病理的影响

Effect of Pseudostellaria heterophylla polysaccharides on anti-oxidation capacity and pancreatic pathology of diabetic mouse

摘要: 目的:观察太子参多糖对糖尿病小鼠的抗氧化功能和胰腺形态的影响。方法:雄性小鼠,尾静脉注射四氧嘧啶90mg/kg建立小鼠糖尿病模型,太子参多糖按0.375、0.75、1.5g/kg三种剂量给药,测定小鼠血清超氧化物歧化酶(SOD)水平和丙二醛(MDA)含量,观察胰腺病理组织学变化。结果:太子参多糖能显著提高实验性糖尿病小鼠血清SOD水平,降低MDA含量,减轻胰腺病理组织学变化。结论:太子参多糖能明显改善糖尿病小鼠抗氧化功能,保护胰腺。

Abstract: Objective:To observe effect of Pseudostellaria heterophylla polysaccharides on anti-oxidation capacity and pancreatic pathology diabetic rats. Methods:The experimental diabetic mice model were established by alloxan 90mg/kg iv. Pseudostellaria heterophylla polysaccharides were administered at the doses of 0.375, 0.75 , 1.5g/kg for 3 weeks. The serum superoxidedismutase (SOD) activities and malondialdehyde (MDA) contents were determined and the pancreatic pathology was observed microscopically. Results:Pseudostellaria heterophylla polysaccharides could sgnificanty increase SOD activities and decrease MDA contents. The pathological damage in diabetic mice was alleviated. Conclusion:Pseudostellaria heterophylla polysaccharides could probably improve anti-oxidation capacity and pancreatic pathology in diabetic mice.