Abstract: Objective:Cholesterol-lowering effect of soybean oligopeptides were studied.Method:In the experimental environment, 90 male SD rats at 5 weeks old had been randomly divided into 6 groups, Ⅰ (control group) , II (protein) , III (polypeptides) , IV (oligopeptides group 1) , V (oligopeptides group 2) and VI (oligopeptides group 3) , high cholesterol model of these rats had been constructed at first, then the high cholesterol had been used to each group, at the same time, soy protein had been used to group II, soybean polypeptide had been used to group III, different doses of soy oligopeptides had been given to group IV, V and VI, drinking water with the same volume had been given to group I.The stools, blood serums and livers were collected and triglyceride contents, fecal weight and the steroid content were determined after 6 weeks.Results:The cholesterol and triglyceride content in serum and liver were reduced at different levels in group II, III, IV, V and VI, and the defecation and fecal steroid content of those groups were increased.Those results in group IV, V and VI were dose dependently, and the cholesterol-lowering effect was significantly in the group with the highest dose.Conclusion:Cholesterol-lowering effects of soybean oligopeptides were stronger than soybean protein and polypeptide, and this effect was dose-dependently.