Abstract: Objective:Extractive of patrinia were detected for its antioxidant effect in mice.Methods:D-galactose saline sterile solution was injected in shoulder and neck subcutaneous.After that the aging model was manufactured.Producted four dose groups which were low, medium, high and top by adding different amounts of patrinia extracted in four groups of ordinary fodder.Different fodder were fed mices.After eight weeks, researchers produced the test sample by getting blood from the six group mice after excising eyes, dislocating executed, tissuing sampling.Then the MDA content, the GSH-PX and SOD activity in the serum, liver and brain fissure were measured.At the same time the CAT activity in the liver and serum were measured Results:The role of Patriniace extract:Significantly reduced the MDA content in serum and tissues in mices.Improved the activity of SOD, GSH-PX and CAT in mices.Conclusion:Patriniace extract had the significant antioxidant activity in vivo.