氟苯尼考-β-环糊精包合物的结构表征

Structure identification of inclusion complex of Florfenicol with β-cyclodextrin

摘要: 目的:利用超声波法制备氟苯尼考-β-环糊精包合物,并对其结构进行表征。方法:以β-环糊精为包合剂,采用超声法制备氟苯尼考包合物,工艺参数为氟苯尼考与β-环糊精投料比1:1（mol/mol）,超声温度60℃,超声时间5h。然后分别采用傅里叶红外光谱法（FIIR）、X-射线粉末衍射法（XRD）对包合物进行结构表征。结果:在该制备工艺条件下包合物的得率为93.52%,包合率为38.09%;且经过FIIR和XRD确证其包合物已形成。结论:采用本实验工艺具有较好的得率,氟苯尼考被β-环糊精包合后呈现出新的物相特征。

Abstract: Objective:To prepare and identify the inclusion complex of florfenicol with β-cyclodextrin.Methods:The inclusion complex was obtained by the ultrasonic method, the preparation conditions were as follows:ratio of Florfenicol and β-cyclodextrin was 1:1 (mol/mol) , ultrasound temperature was 60℃, ultrasound time for 5h, and identified the structure of inclusion complex by the methods of Fourier infrared spectrum (FIIR) and X-ray powder diffractometry (XRD) .Results:The yield of inclusion complex was 93.52% and the inclusion ratio of inclusion complex was 38.09% under these conditions.At the same time, the formation of inclusion complex was proofed by FIIR and XRD.Conclusion:This technology had good yield and the Florfenicol-β-cyclodextrin inclusion complex exhibited some new physical characteristic.