Abstract: Four phthalate acid esters in cream essence, such as dimethyl phthalate (DMP) , diethyl phthalate (DEP) , dibutyl phthalate (DBP) and benzyl butyl phthalate (BBP) , were determined by reverse phase liquid chromatography. The conditions for extraction were researched. Orthogonal design experiment was carried out to optimize the 3 dominant factors (hexane volume, ultrasonic time, water temperature) affecting extraction recovery. The optimum conditions for solid phase extraction were determined as follows:hexane volume 10mL, ultrasonic time 25min, water temperature 15℃. Results showed that the recoveries of the four phthalates were 90%⁹4%.There was a good linear relationship between peak area and concentration of 4 phthalate esters in range of 0.5²0mg/L.