Abstract: Spray drying was applied to prepare microencapsulated glutathione, adopted corn germ as the main raw material, glutathione as core-material and arabic gum and gelatin as wall-material.Optimization of microencapsulated was carried out through mono-factor and orthogonal experiments:the optimum ratio of arabic gum and gelatin was 3:2, the solids concentration was 20%, the proportion of wall-material to core-material was 1:20, the microencapsulating rate could be up to 83.28%.